Best Ergonomic Mice

Ultimate wrist-friendly design. This mouse turns your hand shake into your mouse grip – you hold it at a natural vertical angle. The MX Vertical’s shape keeps your wrist in a neutral position, which can significantly reduce muscle strain over long periods. Despite the unconventional form, it still offers 2 customizable thumb buttons and a precise sensor, making it productive once you adjust. For office use or general computing, many users swear by the relief it provides compared to flat mice.

Premium comfort and productivity. The MX Master series looks like a regular mouse but with a large, sculpted silhouette that fills your palm. It’s designed for ultimate comfort in a traditional grip – notice the thumb rest and the supportive curves. Beyond comfort, it’s packed with features: an adaptive scroll wheel that shifts from ratchet to free-spin, a thumb scroll wheel for horizontal nav, and software to customize gestures. It’s heavier and not meant for rapid FPS flicks, but for work and everyday use it’s hard to beat. The latest model (MX Master 4) even adds subtle haptic feedback in the scroll wheel for a premium feel. If you want an ergonomic mouse that boosts productivity, this is the gold standard.

Affordable ergonomic alternatives. You don’t have to spend a lot for a healthier grip. The Anker Wireless Vertical Mouse and Logitech’s Lift are examples of budget-friendly vertical mice that offer a comfortable handshake position for a fraction of the cost of the MX Vertical. The Logitech Lift is essentially a smaller, more affordable cousin of the MX Vertical – great for small to medium hands – while the Anker model provides basic functionality (two buttons + DPI switch) in a vertical design. They lack the polish and advanced features of the high-end options, but are fantastic entry points if you want to try an ergonomic shape to alleviate discomfort.